Samuel Umtiti has been ruled out of Barcelona's vital La Liga clash with Atletico Madrid on Wednesday because of a knee-ligament strain.
"Umtiti suffered a lateral collateral ligament strain in his left knee during training this morning," a club statement read.
The France international's absence opens the door for Javier Mascherano to return alongside Gerard Pique at the heart of the Barca defence.
Both sides come into the game in free-scoring form after hitting five past Leganes and Sporting Gijon, respectively.
However, Luis Enrique believes Atletico will revert to type when they travel to the Catalonia and rely on their watertight defence to try and hold out against Lionel Messi, Luis Suarez and Neymar.
"Many teams now defend deep against Atletico and give them the ball, so they are obliged to play more in tight spaces. I don't expect that against us," Enrique said.
"They can press high or, without doubt, they are the best team at defending close to their own area. That explains the complexities in playing against Atletico Madrid.